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E2480. Hypercoagulability in Covid-19 Patients Compared to Septic Patients
Authors
  1. Donald Lee; Staten Island University Hospital
Objective:
Covid-19 infections are primarily associated with compromised respiratory function leading to advanced pulmonary support and intervention. However, empiric data suggest that disease courses of covid-19 patients have been complicated by hypercoagulable states not limited to cerebrovascular accidents and pulmonary thromboemboli. This is supported by laboratory and imaging studies. It is also known that patients in a pro-inflammatory state such as acute sepsis are also prone to hypercoagulability such as deep vein thrombosis or disseminated intravascular coagulation. This institutional study seeks to compare the risk of hypercoagulable states in covid-19 infected patients compared to the general acutely septic patient population.

Materials and Methods:
Retrospective chart review will be performed to identify covid-19 positive patients confirmed via laboratory testing. Within the patient pool, those with radiological imaging confirmed coagulopathies such as pulmonary embolus or cerebrovascular accident will be identified to calculate the proportion of covid-19 patients with concurrent coagulopathies. Patient data to be garnered include patient demographics, relevant comorbidities that may contribute to a hypercoagulable state, laboratory/serological data, length of hospitalization, and various parameters to assess severity of covid-19 infection. The same procedure will then be applied to gather data regarding acutely septic patients.

Results:
Data is currently being collected. Covid-19 patients and acutely septic patients with coagulopathies will be stratified based on demographic data and relevant comorbidities to better assess and compare the risk of hypercoagulability in both groups.

Conclusion:
Increased risk of hypercoagulability in covid-19 patients may prompt further investigation into pathogenesis of covid-19 induced coagulopathies and management decisions such as use of antithrombotics. This institutional retrospective chart review seeks to compare the risk of hypercoagulability in covid-19 patients compared to acutely septic patients. Findings may prompt further investigation into the pathogenesis of covid-19 induced coagulopathies as well as management of covid-19 infected patients such as use of antithrombotics.