Abstracts

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E2213. Clear Cell Papillary RCC: How to Recognize This New Entity Without a Microscope
Authors
  1. Iris Chen; University of California, Los Angeles
  2. Elise Nguyen; University of California, Los Angeles
  3. Michelle Melany; University of California, Los Angeles
  4. Corinne Deurdulian; University of California, Los Angeles
Background
Clear cell papillary renal cell carcinoma (RCC) is a recent addition to the World Health Organization classification of renal tumors.

Educational Goals / Teaching Points
The teaching points of this education exhibit include understanding the imaging, clinical, and histopathologic characteristics of clear cell papillary RCC. The presentation will discuss the epidemiology, pathophysiology, clinical presentation, treatment, and prognosis of clear cell papillary RCC. We will review the histopathology findings of clear cell papillary RCC and how it's distinct from other RCC subtypes. This presentation will also delineate the CT and MR imaging characteristics of clear cell papillary RCC. Lastly, we will practice identifying the various subtypes of RCC on imaging with case presentations of biopsy-proven clear cell papillary RCC to improve diagnostic accuracy.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
Clear cell papillary RCC is an indolent subtype of RCC characterized by cells with clear cytoplasm in a papillary and tubular architecture. These tumors tend to be small in size, unifocal, and lack signs of aggressive malignancies such as necrosis or renal sinus and vascular invasion. Key imaging features in clear cell papillary RCC include cystic and solid components, T2 hyperintensity, and early arterial enhancement. These imaging findings are similar to those found in clear cell RCC and papillary RCC, and it is crucial to recognize the key differences for diagnostic, prognostic, and therapeutic purposes.

Conclusion
It is important to distinguish this new and distinct entity from similar RCC subtypes, including clear cell RCC and papillary RCC, on various imaging modalities, which may help clinicians more quickly and accurately identify and diagnose renal masses prior to biopsy.