E2070. Extramedullary Hemopoiesis in Thalassemia: A Forgotten Diagnosis and a Great Mimicker of Malignancy
  1. Elliot Fishman; Johns Hopkins Hospital
  2. Satomi Kawamoto; Johns Hopkins Hospital
Extramedullary Hemopoiesis and Thalassemia are two fairly uncommon but important diagnoses that often are first suggested by radiology and radiology is key to suggest the diagnosis. In this exhibit, we will review some of the important CT imaging findings of Extramedullary Hemopoiesis and of Thalassemia and help with the potential differential diagnosis in these cases. Confusion wth malignancies like lymphoma and leukemia are a challenge but understanding the various pathologies can help narrow down our differential diagnosis. This exhibit will also provide correlation of the imaging findings with the clinical findings.

Educational Goals / Teaching Points
1. Understand the key imaging findings in thalassemia 2. Understand the spectrum of involvement in extramedullary hemopoiesis 3. Understand how extramedullary hemopoiesis can simulate other pathologies including lymphoma, metastases and primary lung cancer to name a few 4. Understand the role of CT in making the diagnosis of extramedullary hemopoiesis and how it mimics other pathologies

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
a. Review of the CT findings in thalassemia b. Understand the spectrum of involvement of extramedullary hemopoiesis in the patient with thalassemia c. Examples of illustrative cases of extramedullary hemopoiesis d. Pearls and pitfalls of extramedullary hemopoiesis simulating other disease processes e. Conclusions and summary statements

Extramedullary Hemopoiesis in Thalassemia can be suggested by radiology based on CT imaging findings but can be a potential pitfall and be confused with other pathologies including lymphoma and leukemia. An understanding of the various CT findings in the chest and abdomen can help avoid these pitfalls.