E1847. Hematologic Malignancies: Manifestations in the Thorax
  1. Juliana Sitta; University of Mississippi Medical Center
  2. Candace Howard; University of Mississippi Medical Center
Hematologic malignancies commonly present a challenge to radiologists evaluating chest computed tomography (CT). Different underlying disease characteristics, clinical stages, immunity levels, and treatment modalities can manifest in the lung with a spectrum of overlapping features. Apart from potential infections, complications from drug toxicity, hematopoietic precursors in transplantation, and malignancy infiltration may be seen. Essential clinical information must be correlated with imaging patterns to properly focus the differential diagnosis of chest imaging findings.

Educational Goals / Teaching Points
To review common and uncommon thoracic complications correlated with clinical stage and findings in patients with hematologic malignancies. Discuss imaging findings of thoracic complications of hematologic malignancies. Learn how to approach and narrow the differential diagnosis of imaging patterns found on thoracic imaging in these patients. Analyze a case-based review of common and uncommon complications

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
This presentation will review the spectrum of complications of hematologic diseases manifested in thoracic imaging, including common and uncommon findings. We include a comprehensive review of findings in secondary infiltrative diseases, infections, and treatment complications (e.g., chemotherapy, immunosuppressant therapy, hematopoietic precursor transplantation). We will recommend a systematic approach to narrow down the diagnosis based on chest CT findings and clinical information. Finally, we will provide a case-based review of chest CT findings in patients with hematologic malignancies.

Chest CT plays an essential role in the diagnosis and follow up of patients with hematologic malignancies. Findings are frequently deemed non-specific or indeterminate due to the broad range of differential diagnoses with overlapping imaging features. Indeterminate reports often require further investigation with invasive procedures, potentially increasing the risk of additional complications leading to further morbidity and mortality. CT can help clinicians narrow down the proper differential diagnosis and improve patient management when reviewed with appropriate clinical information.