E1334. Chemotherapy Agents in Genitourinary Malignancies
  1. Mohammed Saleh; MD Anderson Cancer Center
  2. Jane Shin; The University of Texas Health Science Center at Houston
  3. Sanaz Javadi; MD Anderson Cancer Center
  4. Sarah Palmquist; MD Anderson Cancer Center
  5. Wui Chong; MD Anderson Cancer Center
  6. Revathy Iyer; MD Anderson Cancer Center
  7. Priya Bhosale; MD Anderson Cancer Center
With the evolution of cancer treatment, newer therapies have emerged which have been helpful in the treatment of genitourinary (GU) malignancies. These therapies have different mechanisms of action and target a specific gene or the immune system. Immunotherapy may incite the immune system into a response pattern which may be different from conventional chemotherapy. Though these treatments are supposed to attack the cancer cells they may also damage the normal healthy tissues. In this presentation we will discuss the different therapies, their mechanism of action, and the resulting complications with emphasis on their radiologic presentation.

Educational Goals / Teaching Points
In this presentation we will describe the different current and investigational chemotherapy agents used for GU malignancies, describe the mechanism of action of the agents used in treatment of GU malignancies, demonstrate findings of response, or lack thereof, via cross sectional imaging, discuss possible complications for each chemotherapy drug and imaging findings of these complications, and describe the role of the radiologist in portraying these findings to the primary team.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
This presentation will focus on the genitourinary system. In the presentation we will discuss imaging findings as seen on ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography/computed tomography.

As the treatment for genitourinary malignancies advances, radiologists must become familiar with newer treatments and the imaging manifestations of any complications that might subsequently arise.