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E1270. Prostate MRI Characteristics in Patients With Inflammatory Bowel Disease
Authors
  1. Hiroaki Takahashi; Mayo Clinic
  2. Adam Froemming; Mayo Clinic
  3. David Bruining; Mayo Clinic
  4. R Karnes; Mayo Clinic
  5. Rafael Jimenez; Mayo Clinic
  6. Naoki Takahashi; Mayo Clinic
Objective:
To evaluate the characteristics of prostate MRI in patients with inflammatory bowel disease (IBD).

Materials and Methods:
3140 patients with prostate MRI were evaluated. Coexisting IBD, PI-RADS score, and pathological results of prostate lesions (clinically significant prostate cancer [csPCa]: Gleason score [GS] 7+, Non-csPCa: benign or GS 6) were assessed. ADC value of peripheral zone parenchyma was measured and compared by unpaired t-test. The distribution of PI-RADS scoring and pathological result was assessed by chi-square test.

Results:
71 patients had IBD (IBD group), whereas the remaining 3069 patients did not (Non-IBD group). The ratio of abnormal MRI (PI-RADS 3, 4 or 5) to normal MRI (PI-RADS 1, 2) was 1.03 (36/35) in IBD group and 0.88 (1436/1633) in Non-IBD groups (p=0.513). Total of 1285 patients underwent biospy or prostatectomy. The ratio of csPCa to Non-csPCa at pathology was 0.55 (12/22) in IBD group and 1.27 (699/552) in non-IBD groups (p=0.017). Positive predictive value of abnormal MRI for csPCa was significantly lower in IBD group (39%, 19/31) compared to Non-IBD group (63%, 657/1047) (p=0.007). The mean ADC value (10-6mm2/s) of peripheral zone parenchyma was significantly lower in IBD group (mean ± SD: 1536 ± 173) than Non-IBD group (1620 ± 241) (p<0.019).

Conclusion:
The ratio of csPCa to Non-csPCa at pathology and positive predicve value of abnormal MR for csPCa were lower in patients with IBD group compared to Non-IBD group. This may be secondary to low ADC value of the peripheral zone parenchyma making the interpretation of MR more dififcult.