E1110. The Myth of Metabolic and Toxic-Induced Encephalopathy: What the Radiologists Should Know
  1. Ayman Nada; University of Missouri, Radiology Department
  2. Carlos Leiva-Salinas; University of Missouri, Radiology Department
  3. Eman Mahdi; University of Missouri, Radiology Department
  4. Esmat Mahmoud; National Cancer Institute, Cairo University
  5. Joseph Cousins; University of Missouri, Radiology Department
  6. Humera Ahsan; University of Missouri, Radiology Department
1. Describe the complexity of metabolic and toxic induced encephalopathy. 2. Recognize the wide spectrum of metabolic and toxic etiologies causing encephalopathy. 3. Discuss the typical and atypical imaging features of these various metabolic and toxic disorders and correlate with clinical and pathological data. 4. Illustrate a radiological approach to help reach a specific diagnosis.

Educational Goals / Teaching Points
1. Discuss the pathogenesis of the metabolic disorders causing encephalopathy. 2. Enumerate toxic compounds that potentially result in encephalopathy. 3. Recognize the different radiological modalities that help to reach a diagnosis. 4. Describe how advanced MRI techniques can help to differentiate among various disorders. 5. Illustrate the typical radiological criteria for each pathological entity. 6. Discuss the key point to differentiate among these etiologies.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
Various metabolic disorders and toxins can affect the brain and result in neurological dysfunction. Imaging of the patient with acute neurological dysfunction could narrow the differential diagnosis and help to reach the proper one. The topographic distribution of various disorders can rule out other neurological disorders.

The knowledge of typical imaging features of the various metabolic disorders and toxic induced encephalopathy help to narrow the differential and suggest a proper diagnosis.