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E1008. Effects of a 6-Month Transcranial Direct Current Stimulation on Cerebral Glucose Metabolism in Alzheimer’s Disease
Authors
  1. Yong An Chung; Department of Nuclear Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea
  2. In Uk Song; Department of Neurology, Incn St. Mary's Hospital, The Catholic University of Korea
  3. Hyeonseok Jeong; Department of Nuclear Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea
Objective:
The purpose of this study was to investigate the effects of long-term tDCS on cognitive function and regional cerebral metabolic rate for glucose (rCMRglc) in patients with early-stage AD.

Materials and Methods:
Patients with early-stage AD were randomized to receive either active (n = 11) or sham tDCS (n = 7) over the dorsolateral prefrontal cortex (DLPFC) every day for 6 months (anodal left/cathodal right, 2 mA for 30 minutes). Patients underwent a neuropsychological test battery and brain 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) scan before the first stimulation and after the end of a 6-month treatment period.

Results:
Results on the cognitive data revealed significant group-by-time interaction effects for global cognitive performance, frontal/executive functions, and attention, measured with Mini-Mental State Examination (MMSE), contrasting program, and Stroop word test, in favor of the active group. Additionally, a significant group-by-time interaction effect was found for rCMRglc in the left middle/inferior temporal gyrus, where rCMRglc was preserved in the active group but decreased in the sham group. The results from our study suggest that tDCS over the DLPFC for 6 months can improve cognitive functions and regional cerebral glucose metabolism, supporting the therapeutic potential of long-term tDCS for patients with early-stage AD.

Conclusion:
We examined the effects of long-term tDCS over the DLPFC in AD patients. Active tDCS improved global cognitive performance and frontal/executive functions. Active tDCS improved cerebral glucose metabolism in middle/inferior temporal gyrus. Long-term tDCS may be a valuable treatment option for AD.