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Objective:
This study aims to explore the value of tissue diffusion quantitative analysis of ultrasonic elastography in early chronic kidney disease (CKD) diagnosis.

Materials and Methods:
Fifty-four patients with early CKD treated at our hospital were selected as the observation group, and 40 healthy individuals who underwent physical examinations at the same hospital were selected as the control group. The renal parenchyma of participants was examined using ultrasonography, color Doppler, and tissue diffusion quantitative analysis of ultrasonic elastography. Renal diameter lines, interlobular blood flow parameters, and 11 elastic characteristic values were analyzed and compared between the groups. The area under the ROC curve, cutoff values, sensitivity, and specificity were calculated using ROC curve analysis.

Results:
No significant difference in the interlobar artery blood flow parameters and various diameter lines of the renal meridians between the two groups were noted. In the observation group the mean (MEAN) decreased, and the blue area ratio (AREA %) and skewness (SKEW), increased, compared to the control group (p < 0.05). The ROC curve revealed that area %, mean, and skew had significant diagnostic value (AUC > 0.7). The best cutoff value of the mean was 106, with a sensitivity and specificity of 80% and 81%, respectively.

Conclusion:
Tissue diffusion quantitative analysis of ultrasonic elastography can quantitatively evaluate renal parenchymal damage through diffusion quantitative parameters for early CKD.