E5060. Analysis of Thyroid and Arytenoid Cartilage Molecular Calcification and Glucose Metabolism in Aging Adults with 18F-NaF and FDG PET/CT
Authors
Niloofaralsadat Motamedi;
Children’s Hospital of Philadelphia
Shashi Singh;
Stanford University
William Raynor;
Rutgers Robert Wood Johnson Medical School
Thomas Werner;
Hospital of the University of Pennsylvania
Abass Alavi;
Hospital of the University of Pennsylvania
Mona-Elisabeth Revheim;
The Intervention Center, Division for Technology, Rikshospitalet
Drew Torigian;
Hospital of the University of Pennsylvania
Objective:
18F-sodium fluoride (18F-NaF) and 18F-FDG uptake in the cartilage is a marker of calcification and inflammation, respectively. The aim of this study was to investigate the role of 18F-NaF and 18F-FDG PET/CT for the evaluation of physiological, molecular calcification, and glucose metabolism of thyroid and arytenoid cartilages with age.
Materials and Methods:
This retrospective study analyzed 18F-NaF and FDG PET/CT images from the CAMONA study (ClinicalTrials.gov identifier: NCT01724749). We included a total of 127 healthy subjects (65 women and 62 men) with a mean age of 48.46 ± 14.13 (range 21–75) years for 18F-NaF PET/CT, and a total of 114 healthy subjects (women females and men males) with a mean age of 49.05 ± 14.29 (range 21–75) years for FDG PET/CT analysis for the evaluation of molecular calcification and glucose metabolism, respectively, in the thyroid and arytenoid cartilages. ROIs were placed around the thyroid and arytenoid cartilages on PET/CT images using OsiriX software. The SUVmean was measured separately for 18F-NaF and FDG PET/CT images. Subsequently, Pearson correlation coefficients were calculated using Statistical Package for Social Sciences (SPSS) software version 28.0 to evaluate the effects of aging on the uptake of 18F-NaF and FDG in the thyroid and arytenoid cartilages.
Results:
To our knowledge, this is the first study to assess the effects of aging on the uptake of 18F-NaF and FDG in the thyroid and arytenoid cartilages. A significant positive correlation was observed between age and SUVmean of 18F-NaF in the thyroid and arytenoid cartilages (r = 0.18, p = 0.043). This result indicates that molecular calcification of these cartilages increases with aging. Meanwhile, a negative trend was observed between age and SUVmean of FDG in the thyroid and arytenoid cartilages, although without statistical significance (r = -0.09, p = 0.319).
Conclusion:
This study presents a novel methodology for the determination of physiological, molecular calcification, and glucose metabolism of laryngeal cartilage with aging. Molecular calcification of thyroid and arytenoid cartilages increases with age, whereas glucose metabolism of these cartilages does not have a statistically significant correlation with age.
