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Background
Diabetes mellitus (DM) is chronic epidemic disease and is a worldwide health and economic problem. According to CDC national diabetes statistics report 2020, 34.2 million Americans (10.5%) had diabetes in 2018 and its prevalence is expected to increase by 50% in 2030. It is a metabolic disorder characterized by hyperglycemia and has two major types: type 1 DM is due to failure of pancreatic insulin production, and type 2 DM is due to increased insulin resistance. The hyperglycemia that characterizes diabetes is radiologically invisible; however, diabetic complications in multiple organs can be detected radiologically.

Educational Goals / Teaching Points
Brief overview of the diabetic statistics and prevalence, followed by pictorial review of multiorgan acute and chronic, common and uncommon diabetic complications, with underlying pathophysiology and treatment options.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
We will provide a pictorial review of multiorgan diabetic complications using different imaging modalities including ultrasound, CT, MRI, and nuclear medicine imaging studies. The complications will be characterized as macrovascular, microvascular, neuropathic, due to increased risk of infection, and miscellaneous.

Conclusion
Diabetes results in myriad of multiorgan clinically important complications that account for major morbidity and mortality. Radiological manifestations of DM are proportional to the duration of disease, specifically micro and macroangiopathy; however, increased risk of infection result in acute complication which require emergent attention. Radiologists play an important role by making an early diagnosis and guiding further management of life-threatening complications.