4502. Can Apparent Diffusion Coefficient Predict the Grade, Genotype, or Proliferation Index of Oligodendrogliomas?
Authors * Denotes Presenting Author
  1. Fatima Mubarak *; Aga Khan University Hospital
Genetic subsets of oligodendrogliomas (OD) have distinct chromosomal and biophysical profiles. Pretherapeutic tumor grade and genotype analysis is a challenging aspect of management, with 1p/19q codeletion status and grade of OD among the most important considerations for clinical decision making. The study aimed to determine the correlation of ADC with Ki-67, grade, and 1p/19q codeletion in OD at a tertiary care hospital within a low-middle income country.

Materials and Methods:
Seventy-three patients with histopathological diagnosis of OD were selected, and their preoperative 1.5-T magnetic resonance imaging (MRI) scans were reviewed through parameters including diffusion weighted image (DWI), susceptibility-weighted imaging, and apparent diffusion coefficient (ADC). These images were correlated with patients’ histopathological and chromosomal testing. Tumor border irregularity, homogeneity, contrast enhancement, and other MRI characteristics were also studied. For analysis, descriptive statistics were generated, and normality was evaluated for ADC value, age, and Ki-67 tumor proliferation index.

Ki-67 tumor proliferation index was high in 33 tumors. It was found to be statistically significant (<em>P</em> = 0.048) with respect to ADC, showing that1p/19q codeleted tumors have a difference in their Ki-67 index. Ki-67 also showed a significant relationship (<em>P</em> < 0.05) with grade of OD. However, there was no statistically significant relationship between 1p19q chromosomal codeletion and ADC. Linear regression was carried out as the dataset was continuous. Univariate analysis showed no significant result with all <em>P</em> values above 0.10.

Mean ADC is a viable tool to predict Ki-67 and assist prognostic clinical decisions. However, mean ADC alone cannot predict 1p/19q codeletion and tumor grades in OD. Further supplementation with other radiological modalities may provide greater yield and positive results.