3230. Altered Functional and Morphological Brain Networks in Major Depressive Disorder: Findings from the Resting-State and Structure Analysis
Authors* Denotes Presenting Author
Kai Xu *;
Strategic Support Force Medical Center
Objective:
Depression is a mental disorder characterized by low mood and anhedonia that involves abnormalities in multiple brain regions and networks. Epidemiological studies demonstrated that depression has become one of the most important diseases affecting human health and longevity. The pathogenesis of the disease has not been fully elucidated. Recent developments in neuroimaging have heightened the need for investigating the disruptions in the structure and function of brain in major depressive disorder (MDD). In this study, we employed resting-state functional magnetic resonance imaging (fMRI) and structure MRI (sMRI) to examine the global and local-brain functional and morphological networks among MDD patients and healthy controls.
Materials and Methods:
The study included 55 patients with MDD and 46 normal controls (NC) subjects were collected, data of brain 3D high resolution, T1-weighted and resting-state images were acquired with a 3.0-T MR system. Construction of functional brain network was preprocessed through the DPARSF tool, and the morphological brain network was constructed through FreeSurfer tool.
Results:
Compared with normal controls, the global features of functional brain network exhibited no significant differences in patients with MDD, but the local features of functional and morphological networks were changed. Morphological brain networks: The transverse temporal gyrus in left hemisphere showed increased gray volume and surface area in patients with MDD compared to NCs (<em>P</em> <0.05). Functional brain networks: The functional connectivity (FC) of multiple nodes in the default mode network (DMN) of depression patients was abnormally increased, especially the left temporal lobe. The betweenness centrality of topology in the left transverse temporal gyrus with MDD altered compared to NCs (<em>P</em> < 0.05).
Conclusion:
Functional and morphological brain network changes of transverse temporal gyrus in left hemisphere are found in patients with MDD. These significant findings could expand our understanding of neurophysiologic mechanisms related to MDD from a network perspective.
