E2731. Exploring Benign Prostatic Hypertrophy Growth Patterns in Men Undergoing Prostate Multiparametric MRI
  1. Thomaz R. Mostardeiro; UT Southwestern Medical Center
  2. Daniel Costa; UT Southwestern Medical Center
  3. Yin Xi; UT Southwestern Medical Center
To determine benign prostatic hypertrophy (BPH) growth patterns based on prostate volumes derived from multiparametric MRI.

Materials and Methods:
In this IRB-approved single-center retrospective study, we identified men with 2 or more multiparametric MRIs performed between 2013 and 2021. Patients with exams performed within less than 6 months were excluded. Prostate volume was calculated using the ellipsoid formula based on the T2-weighted images. Statistical analysis was performed using Wilcoxon rank tests and ANOVA. Growth rates were estimated using a random intercept random slope model.

A total of 705 men with 1574 multiparametric MRIs were identified. The median age was 64 years (SD: 7 years) and the median baseline prostate size was 66 cc (SD: 35 cc). At a median follow-up of 33 months (SD: 18 months), prostate size increased by 4.0 ± 4.0 %/year for all men. The growth rate was significantly slower (p<0.01) for selected groups, such as clinically significant prostate cancer (Gleason 7 or higher; 2.6 ± 5.5 %/year), hormonal therapy (1.0 ± 7.7 %/year), alpha-reductase inhibitors (2.7 ± 5.7 %/year) and advancing age.

Prostate growth rates are variable among men. Demographically, increasing age (especially after 70 years old) and clinically significant prostate cancer, even without therapy, are important factors leading to slower prostate volume growth. Prostate size and growth play an important role in prostate surgical and treatment planning and the radiologist should be familiar with specific patients who may experience decreased growth.