E2615. Uncover the Mysteries of the Spleen: A Comprehensive MR Review of Splenic Pathology
  1. Nathaniel Linna; University of Pennsylvania
  2. Victor Babatunde; University of Pennsylvania
  3. Amr El Jack; University of Pennsylvania
Splenic lesions are usually detected incidentally, and the majority are benign in nature. However, imaging characteristics and clinical history can harbor clues which help to identify lesions that are potentially malignant. Etiologies of abnormalities in the spleen include benign and malignant neoplastic, traumatic, systemic, inflammatory, vascular, and developmental conditions.

Educational Goals / Teaching Points
Through illustrative cases, the objectives of this educational exhibit are to review the normal appearance of the spleen; familiarize the radiologist with the broad spectrum of disorders of the spleen; and examine relevant MR imaging features of indolent and aggressive splenic masses.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
We will briefly review the various imaging modalities of the spleen, and then focus upon standard MR techniques and sequences. We will discuss the normal MR appearance of the spleen and provide an in-depth overview of the common and uncommon pathologies of the spleen including developmental conditions, trauma, systemic disease manifestations, infection, and benign and malignant neoplasms. Mimickers of malignancy will be presented including benign lesions and inflammatory conditions.

While splenic pathology is infrequently encountered and lesions are most often benign, imaging features are often nonspecific. MR imaging features of splenic masses can help to differentiate benign from potentially malignant neoplasms. This comprehensive review of a wide range of splenic lesions will discuss MR imaging features which help to narrow the differential diagnosis and allow appropriate management.