E2544. PET CT in Ovarian Malignancy: A Case-Based Pictorial Review Highlighting the Impact of PET CT on Management and Its Correlation With CA-125
Authors
Miguel Ibarra Lopez;
Rush University Medical Center
Pokhraj Suthar;
Rush University Medical Center
Sumeet Virmani ;
Rush University Medical Center
Background
Cancer antigen 125 (CA-125) is a valuable marker for diagnosing, monitoring treatment response, and recurrence of ovarian malignancies. CA-125 is most useful in post-menopausal women. In pre-menopausal women, CA-125 will be elevated by any condition that disrupts the ovarian epithelial wall (for example fibroids, endometriosis). Therefore, the utility of CA-125 can vary given its nonspecificity in this group. PET-CT offers additional data alongside CA-125 that provides earlier diagnostic information, thus potentially altering the management of patients with ovarian malignancy. This case-based pictorial review focuses on the spectrum of characteristic imaging findings on PET-CT to evaluate patients with ovarian malignancies in correlation with CA-125.
Educational Goals / Teaching Points
This exhibit presents cases with a spectrum of characteristic imaging findings highlighting the importance of PET-CT in the evaluation of patients with ovarian malignancies in correlation with CA-125. Multimodality correlative imaging is provided where available.
Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
In this exhibit we present 10 cases with multimodality correlation that highlights the importance of PET-CT in patients with ovarian malignancies in correlation with CA-125.
Conclusion
PET-CT has higher specificity and sensitivity when compared to CA-125 in diagnosing early-stage ovarian malignancy. A combined effort can be more helpful in-patient management.
