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Background
Non-breast primary malignancies and metastases to the breast are extremely rare, with incidence ranging from 0.04 - 1.3% of all malignancies in the breast. It can be difficult to differentiate between these and primary breast cancers on diagnostic evaluation. Because of the overlapping imaging findings and presenting patient symptoms, biopsy for pathologic diagnosis is often required. Furthermore, increased familiarity of non-breast primary malignancies and metastases to the breast is critical for radiologists and trainees to provide high-quality patient care. This educational exhibit aims to review imaging findings and management recommendation for non-breast primary malignancies and metastases to the breast.

Educational Goals / Teaching Points
The goals of this exhibit are multimodality imaging review of non-breast primary malignancies and metastases to the breast including, but not limited to, CT and PET/CT and multidisciplinary review of the epidemiology, diagnosis, further imaging recommendations, management, prognosis, and common multimodality imaging features of these example cases.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
A case-based review will be provided for the following: B-cell and T-cell lymphoma, sarcoma (extraosseous osteosarcoma, angiosarcoma and primary spindle cell), desmoid (fibromatosis) tumor, plasmacytoma, and metastases (ovarian cystadenocarcinoma, melanoma, carcinoid, small cell lung carcinoma, clear cell renal cell carcinoma).

Conclusion
Radiologists and trainees should be familiar with the imaging characteristics and diagnosis of non-breast primary malignancies and metastases to the breast to ensure appropriate clinical management and guidance for referring providers and their patients.