E2041. Feasibility of Vascular Imaging Using Stationary Carbon Nanotube Enabled Tomosynthesis Imaging
Diego Hipolito Canario;
Department of Surgery, University of North Carolina at Chapel Hill
Department of Biomedical Engineering, North Carolina State University; Department of Biomedical Engineering, University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill School of Medicine
Department of Physics & Astronomy, University of North Carolina at Chapel Hill
Department of Radiology, University of North Carolina at Chapel Hill
Department of Radiology, University of North Carolina School of Medicine; UCLA Health Santa Clarita Imaging and Interventional Center
Conventional digital subtraction angiography (DSA) allows the high-resolution visualization of vessels in the brain, heart, or peripheral vasculature. However, the approach is 2D, compressing the 3D information into a single image. Our team has developed a stationary tomosynthesis imaging approach utilizing a carbon nanotube based linear x-ray source array. The system enables the acquisition of multiple x-ray projections without movement of the x-ray source. These projections can then be reconstructed into a pseudo-3D imaging stack. The goal of this study was to evaluate the feasibility of this approach to perform digital subtraction tomosynthetic angiography (DSTA), the tomosynthesis equivalent of DSA, following penetrating injury in an animal model to determine whether angiography was of diagnostic quality and whether active hemorrhage could be detected.
Materials and Methods:
The experimental study was performed on three domestic swine. For each animal, access was gained to the right common femoral artery and a 5-French diagnostic flush catheter was positioned above the celiac axis. A liver laceration was created to simulate a penetrating injury under ultrasound guidance. Pre- and post-injury image acquisition was performed using DSTA to evaluate for vessel opacification and evidence of active hemorrhage. The animals were sacrificed following image acquisition.
DSTA resulted in diagnostic opacification of the hepatic arteries in all animals both pre- and post-injury. Following penetrating trauma to the liver, there was evidence of focal contrast blush suggestive of active extravasation identified in the region of the injury in all animals.
In this animal study, DSTA performed using a stationary tomosynthesis imaging approach was successful in obtaining diagnostic quality angiographic images and in the identification of active hemorrhage in the setting of penetrating trauma to the liver. This technology offers the potential to perform pseudo-3D vascular imaging without system motion in a clinically relevant time frame. This technique could have eventual applications in clinical settings where portable, non-rotational imaging would be advantageous, such as the intensive care unit or military outposts.