ARRS 2022 Abstracts

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E1144. Triple Negative Breast Cancer: Comprehensive Review of the Clinical, Pathologic, and Multi-modality Imaging Features
Authors
  1. Iris Chen; UCLA
  2. Stephanie Lee-Felker; UCLA
Background
Triple-negative breast cancer (TNBC) is a subgroup of breast cancer without estrogen, progesterone, or human epidermal growth factor receptors. TNBC represents 15–20% of all breast cancers and is associated with BRCA.

Educational Goals / Teaching Points
Key imaging features of TNBC on mammography include irregular shape, ill-defined, and spiculated margins. On ultrasound, TNBC tends to appear as a hypoechoic or complex mass with an irregular shape and non-circumscribed margins. MRI is the most accurate imaging modality to evaluate TNBC and demonstrates intra-tumoral T2 hyperintense signal and rim enhancement on post-contrast images. TNBC has a poor prognosis given its aggressive course, high rates of recurrence, and limited therapeutic options given its lack of target receptor expression. Treatment often involves chemotherapy, and MRI can be used to predict chemotherapy efficacy and pathologic complete response.

Key Anatomic/Physiologic Issues and Imaging Findings/Techniques
Key imaging features of TNBC on mammography include irregular shape, ill-defined, and spiculated margins. On ultrasound, TNBC tends to appear as a hypoechoic or complex mass with an irregular shape and non-circumscribed margins. Magnetic resonance imaging (MRI) is the most accurate imaging modality to evaluate TNBC and demonstrates intra-tumoral T2 hyperintense signal and rim enhancement on post-contrast images. TNBC has a poor prognosis given its aggressive course, high rates of recurrence, and limited therapeutic options given its lack of target receptor expression. Treatment often involves chemotherapy, and MRI can be used to predict chemotherapy efficacy and pathologic complete response.

Conclusion
Prompt recognition and diagnosis of TNBC by imaging is essential.